[Optimization of contrast injection protocol for coronary CTA: adjustment of injection iodine volume on test bolus parameters and patients' sex and BSA].

The purpose of this study was to correlate test bolus (TB) parameters and patient information and cardiac function with main bolus (MB) contrast density for 64-slice computed tomography, and to evaluate MB contrast density on a fixed injection rate, in comparison with an injection rate adjusted with TB parameters and patient information. A total of 256 patients underwent coronary CT angiography. In 126 patients (group 1), contrast material was administered at a flow rate of 4 ml/sec. The peak enhancement, the time needed to reach the peak of the TB and cardiac function of the MB were calculated for each patient in this group. The dependency of MB contrast attenuation on these parameters was evaluated. Significant correlations were obtained between the peak density of the TB and the patient's body surface area (BSA) with the enhancement of MB. Furthermore, females showed a higher peak enhancement of MB than males. In view of the results of group 1, in the other 130 patients (group 2) injection protocols were computed by using regression analysis of each patient's attenuation response to a TB and patient sex and BSA. Compared with group 1, the variations of MB contrast density of group 2 were reduced. Optimized contrast injection protocols are useful to reduce variations of MB contrast density, by taking these TB parameters and patient sex and BSA into account.